Cesare Montecucco Selected Research

SNARE Proteins (SNAREs)

1/2022	Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
12/2017	High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.
12/2015	Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction.
1/2013	The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.
5/2003	VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes.

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Cesare Montecucco Research Topics

Disease

19	Tetanus 04/2022 - 05/2003
16	Botulism 01/2022 - 06/2005
16	Paralysis (Palsy) 01/2021 - 11/2006
10	Anthrax 10/2010 - 07/2002
7	Infections 12/2013 - 01/2002
5	Edema (Dropsy) 03/2009 - 04/2005
4	Wounds and Injuries (Trauma) 01/2021 - 01/2017
4	Pain (Aches) 01/2017 - 04/2006
3	Snake Bites (Snake Bite) 01/2020 - 08/2010
3	Necrosis 01/2013 - 02/2005
2	Muscle Spasticity (Spastic) 11/2021 - 01/2021
2	Inflammation (Inflammations) 01/2019 - 01/2013
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2017 - 12/2016
2	Miller Fisher Syndrome (Fisher Syndrome) 01/2017 - 12/2016
2	Guillain-Barre Syndrome 01/2017 - 12/2016
2	Nerve Degeneration 12/2016 - 03/2013
2	Central Nervous System Diseases (CNS Diseases) 02/2007 - 10/2006
1	Bites and Stings (Sting) 01/2020
1	Pathologic Processes 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Diphtheria 06/2016
1	Nervous System Diseases (Neurological Disorders) 12/2015
1	Malaria 12/2013
1	Human Influenza (Influenza) 12/2013
1	Tuberculosis (Tuberculoses) 12/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2013
1	Myotoxicity 01/2012
1	Rhabdomyolysis 01/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2010

Drug/Important Bio-Agent (IBA)

25	Botulinum Toxins (Botulinum Toxin)IBA 04/2022 - 08/2002
23	NeurotoxinsIBA 04/2022 - 06/2005
10	Proteins (Proteins, Gene)FDA Link 11/2021 - 01/2002
6	Metalloproteases (Metalloproteinases)IBA 04/2022 - 06/2004
5	SNARE Proteins (SNAREs)IBA 01/2022 - 05/2003
5	incobotulinumtoxinA FDA Link 12/2015 - 08/2002
4	DisulfidesIBA 11/2019 - 11/2011
3	Peptides (Polypeptides)IBA 04/2022 - 02/2010
3	tetanospasmin (tentoxilysin)IBA 11/2021 - 01/2021
3	AntibodiesIBA 11/2021 - 11/2008
3	VenomsIBA 01/2020 - 01/2012
3	Bacterial ToxinsIBA 06/2018 - 02/2007
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2018 - 12/2016
3	Virulence Factors (Pathogenicity Factors)IBA 02/2013 - 04/2005
3	Phospholipases (Phospholipase)IBA 08/2010 - 12/2008
3	CytokinesIBA 11/2008 - 02/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2008 - 02/2005
2	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 04/2022 - 05/2003
2	EpitopesIBA 11/2021 - 01/2017
2	Formaldehyde (Formol)FDA Link 11/2021 - 04/2006
2	ExotoxinsIBA 11/2021 - 11/2019
2	Diphtheria ToxinIBA 06/2018 - 06/2016
2	AutoantibodiesIBA 01/2017 - 12/2016
2	GangliosidesIBA 01/2017 - 10/2006
2	Adenosine Triphosphate (ATP)IBA 01/2017 - 08/2010
2	Complement System Proteins (Complement)IBA 01/2017 - 12/2016
2	Thioredoxin-Disulfide ReductaseIBA 09/2014 - 01/2013
2	ThioredoxinsIBA 09/2014 - 01/2013
2	VaccinesIBA 12/2013 - 07/2008
2	Phospholipases A2 (Phospholipase A2)IBA 03/2013 - 11/2006
2	LipidsIBA 10/2010 - 11/2006
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 03/2009 - 01/2008
2	CalciumIBA 03/2009 - 02/2005
2	Interleukin-6 (Interleukin 6)IBA 11/2008 - 04/2008
2	Protein Isoforms (Isoforms)IBA 09/2006 - 04/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 09/2006 - 06/2004
2	anthrax toxin (anthrax lethal factor)IBA 04/2004 - 11/2002
1	rimabotulinumtoxinB FDA Link 04/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	Monoclonal AntibodiesIBA 11/2021
1	Therapeutic UsesIBA 11/2021
1	Immunoglobulins (Immunoglobulin)IBA 11/2021
1	gamma-Aminobutyric Acid (GABA)IBA 01/2021
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021
1	NUCC-390IBA 01/2020
1	taipoxinIBA 01/2020
1	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2020
1	ebselenIBA 11/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	LigandsIBA 01/2019
1	Botulinum AntitoxinIBA 01/2018
1	Qa-SNARE Proteins (Syntaxin)IBA 12/2017
1	Vesicle-Associated Membrane Protein 2 (VAMP2)IBA 01/2017
1	Scorpion Venoms (Scorpion Venom)IBA 01/2017
1	trisialoganglioside GT1IBA 01/2017
1	Auranofin (Ridaura)FDA Link 06/2016
1	Pharmaceutical PreparationsIBA 12/2015
1	Oxidoreductases (Dehydrogenase)IBA 09/2014
1	Apyrase (ATP Diphosphatase)IBA 12/2013
1	Influenza Vaccines (Influenza Vaccine)FDA Link 12/2013
1	Type A Botulinum Toxins (Botox)FDA Link 08/2013
1	botulinum toxin type DIBA 05/2013
1	Apoptosis Regulatory ProteinsIBA 02/2013
1	AlarminsIBA 01/2012
1	Transferrin (beta 2 Transferrin)IBA 10/2010
1	early endosome antigen 1IBA 10/2010
1	Caveolin 1IBA 10/2010
1	enhanced green fluorescent proteinIBA 10/2010
1	PotassiumIBA 08/2010

Therapy/Procedure

9	Therapeutics 11/2021 - 08/2002
1	Lasers (Laser) 12/2017